The seeds of A. tetragonophylla are used by the Aborigines for food after grinding to a paste, Isaacs (1987).
Shurcliff (1986) indicates that the seed of A. tetragonophylla is eaten by birds in the far north-west of South Australia but does not say which birds are involved.
Davies (1976, 1978) indicates that A. tetragonophylla pods were of significant importance in the diet of emus in Western Australia.
Five species of mistletoe have been recorded on A. tetragonophylla in the State Herbarium. The most common is Amyema preissii, wire-leaved mistletoe with A. maidenii pale leaved mistletoe and A. quartdang, grey mistletoe. The wide ranging Lysiana exocarpi, harlequin mistletoe is also common with a single record of L. murrayi, mulga mistletoe.