Lange & Graham (1983) conducted experiments on the influence of rabbits on Acacia regeneration in the arid areas. A. oswaldii was amongst the four species tested. Results showed that seedlings were severely pruned even with lowered post-myxomatosis rabbit population densities. Rabbit grazing pressure would significantly affect the recruitment in arid zone Acacia populations.

Despite its wide distribution only three mistletoes have been recorded on A. oswaldii in the State Herbarium. There are two records of Lysiana exocarpi, harlequin mistletoe, more records of Amyema preissii, wire-leaved mistletoe and a couple of records of Amyema maidend, pale-leaved mistletoe.

Everist (1981) records stock poisoning by Acacia oswaldii believing the toxic substance to be cyanides in the leaves.

The small pale flowers and somewhat malodorous leaves are hardly likely to make this a popular species in cultivation. It has a dense growth habit and its wide distribution in the State indicates tolerance of many soil types.